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High Affinity Retinoic Acid Receptor Antagonists: Analogs of AGN 193109

A T Johnson, L Wang, S J Gillett, R A Chandraratna

Bioorg Med Chem Lett. 1999 Feb 22;9(4):573-6.

PMID: 10098666

Abstract:

A series of high affinity retinoic acid receptor (RAR) antagonists were prepared based upon the known antagonist AGN 193109 (2). Introduction of various phenyl groups revealed a preference for substitution at the para-position relative to the meta-site. Antagonists with the highest affinities for the RARs possessed hydrophobic groups, however, the presence of polar functionality was also well tolerated.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP171746217 AGN 193109 AGN 193109 171746-21-7 Price
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