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High-performance Liquid Chromatographic Assay for the Determination of Paracetamol, Pseudoephedrine Hydrochloride and Triprolidine Hydrochloride

High-performance Liquid Chromatographic Assay for the Determination of Paracetamol, Pseudoephedrine Hydrochloride and Triprolidine Hydrochloride

M J Akhtar, S Khan, M Hafiz

J Pharm Biomed Anal. 1994 Mar;12(3):379-82.

PMID: 8031938

Abstract:

The different UV absorption characteristics of paracetamol, pseudoephedrine hydrochloride and triprolidine hydrochloride have been used to facilitate their determination in pharmaceutical preparations by HPLC. The method developed involves isocratic, reversed-phase chromatography. A 'wavelength switching' programme is preferred to the use of a compromise wavelength for all three compounds. This gives reasonable UV responses despite widely different UV characteristics and concentrations of drugs. The limits of quantitation are found to be within 200-700 micrograms ml-1 for paracetamol, 24-84 micrograms ml-1 for pseudoephedrine HCl and 1.0-4.0 micrograms ml-1 for triprolidine HCl. The method performs well in terms of precision and accuracy as indicated by linear regression analysis.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP6138790	Triprolidine hydrochloride		6138-79-0	Price

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