Home
Resources
Publications
High-power Short-Duration Versus Standard Radiofrequency Ablation: Insights on Lesion Metrics

High-power Short-Duration Versus Standard Radiofrequency Ablation: Insights on Lesion Metrics

Felix Bourier, Josselin Duchateau, Konstantinos Vlachos, Anna Lam, Claire A Martin, Masateru Takigawa, Takeshi Kitamura, Antonio Frontera, Ghassen Cheniti, Thomas Pambrun, Nicolas Klotz, Arnaud Denis, Nicolas Derval, etc.

J Cardiovasc Electrophysiol. 2018 Nov;29(11):1570-1575.

PMID: 30168230

Abstract:

Introduction:
Radiofrequency (RF) lesion metrics are influenced by underlying parameters like RF power, duration, and contact force (CF), and utilization of lesion metric indices (ablation index [AI]) is a proposed strategy to predict lesion quality. The aim of this study was to analyze the influence of underlying parameters on lesion metrics of high-power short-duration (HPSD) and standard RF applications using an in silico and ex vivo model.
Methods and results:
An in silico simulation study was designed to simulate HPSD and standard ablations, in which ablation parameters could systematically be varied. For each simulated ablation process (n = 5732), the corresponding AI value was calculated. HPSD and standard RF settings were then applied in a porcine ex vivo model ( n = 120 lesions). The resulting lesion metrics were compared and analyzed regarding underlying parameters. RF applications of 50 W/13 seconds, 60 W/10 seconds, 70 W/7 seconds, and 80 W/6 seconds resulted in lesion volumes not significantly different from standard RF applications (30 W/30 seconds, P > 0.05). HPSD lesion diameters were significantly larger and lesion depths were significantly smaller ( P < 0.01) when compared with standard settings. Prolonging RF duration from 5 to 10 seconds resulted in a +27.5% increase, whereas a prolongation of RF duration from 35 to 40 seconds resulted in a +4.8% increase of AI value only. An increase of CF from 1 to 10 g resulted in a +73.0%, an increase of CF from 20 to 30 g resulted in a +10.1% increase of AI value.
Conclusion:
HPSD RF applications resulted in similar lesion volumes but significantly different lesion geometries when compared with standard setting RF applications.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP88519577-A	W-13		88519-57-7	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: