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High-yield Synthesis of Bioactive Ethyl Cinnamate by Enzymatic Esterification of Cinnamic Acid

High-yield Synthesis of Bioactive Ethyl Cinnamate by Enzymatic Esterification of Cinnamic Acid

Yun Wang, Dong-Hao Zhang, Jiang-Yan Zhang, Na Chen, Gao-Ying Zhi

Food Chem. 2016 Jan 1;190:629-633.

PMID: 26213020

Abstract:

In this paper, Lipozyme TLIM-catalyzed synthesis of ethyl cinnamate through esterification of cinnamic acid with ethanol was studied. In order to increase the yield of ethyl cinnamate, several media, including acetone, isooctane, DMSO and solvent-free medium, were investigated in this reaction. The reaction showed a high yield by using isooctane as reaction medium, which was found to be much higher than the yields reported previously. Furthermore, several parameters such as shaking rate, water activity, reaction temperature, substrate molar ratio and enzyme loading had important influences on this reaction. For instance, when temperature increased from 10 to 50 °C, the initial reaction rate increased by 18 times and the yield of ethyl cinnamate increased by 6.2 times. Under the optimum conditions, lipase-catalyzed synthesis of ethyl cinnamate gave a maximum yield of 99%, which was of general interest for developing industrial processes for the preparation of ethyl cinnamate.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP103366	Ethyl cinnamate		103-36-6	Price

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