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Highly Branched poly(N-isopropyl Acrylamide) Functionalized With an Inducer Molecule Suppresses Quorum Sensing in Chromobacterium Violaceum

Joanna Shepherd, Thomas Swift, Chien-Yi Chang, James R Boyne, Stephen Rimmer, William H C Martin

Chem Commun (Camb). 2019 Aug 13;55(66):9765-9768.

PMID: 31355394

Abstract:

Bacterial quorum sensing has been implicated in a number of pathogenic bacterial processes, such as biofilm formation, making it a crucial target for developing materials with a novel antibiotic mode of action. This paper describes poly(N-isopropyl acrylamide) that has been covalently linked, at multiple chain ends, to homoserine lactone to give a highly branched polymer functionalized with a key messenger molecule implicated in QS. This novel functional material has shown promising anti-QS activity in a Chromobacterium violaceum assay.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
LS74687 Poly(N-isopropyl acrylamide) Poly(N-isopropyl acrylamide) Price
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