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Histological Effects of Pharmacologically Active Human Bile Acid nano/micro-particles in Type-1 Diabetes

Histological Effects of Pharmacologically Active Human Bile Acid nano/micro-particles in Type-1 Diabetes

Sangeetha Mathavan, Corina M Ionescu, Bozica Kovacevic, Momir Mikov, Svetlana Golocorbin-Kon, Armin Mooranian, Crispin R Dass, Hani Al-Salami

Ther Deliv. 2020 Mar;11(3):157-171.

PMID: 32046598

Abstract:

Aim: Gliclazide (G) is a drug prescribed for Type 2 diabetics, although recent studies suggest it has desirable effects in both types of diabetes, Type 1 diabetes and Type 2 diabetes. G has an inconsistent absorption due to poor formulation and bile acids (BAs) have shown significant promise in drug formulation optimization. Hence, the study aimed to examine G effects on histopathological, anti-inflammatory and antidiabetic effects when encapsulated with BAs. Materials & methods: Rats were randomized into eight groups, of which seven were made Type 1 diabetes and treated with various BA-based treatments. Tissue histopathology, inflammation and the bile acid profile were analyzed. Results & conclusion: G capsules showed no histological but the most anti-inflammatory effects, which suggest significant beneficial effects in diabetes treatment.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42417903	Bas Active human			Price

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