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HIV-1 Gag Proteins: Diverse Functions in the Virus Life Cycle

HIV-1 Gag Proteins: Diverse Functions in the Virus Life Cycle

E O Freed

Virology. 1998 Nov 10;251(1):1-15.

PMID: 9813197

Abstract:

The Gag proteins of HIV-1, like those of other retroviruses, are necessary and sufficient for the assembly of virus-like particles. The roles played by HIV-1 Gag proteins during the life cycle are numerous and complex, involving not only assembly but also virion maturation after particle release and early postentry steps in virus replication. As the individual Gag domains carry out their diverse functions, they must engage in interactions with themselves, other Gag proteins, other viral proteins, lipid, nucleic acid (DNA and RNA), and host cell proteins. This review briefly summarizes our current understanding of how HIV-1 Gag proteins function in the virus life cycle.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4241133	HIV-1 gag			Price

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