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HIV gp41 Binding Phenolic Components From Fraxinus Sieboldiana Var. Angustata

HIV gp41 Binding Phenolic Components From Fraxinus Sieboldiana Var. Angustata

Hyoung Ja Kim, Yeon Gyu Yu, Hokoon Park, Yong Sup Lee

Planta Med. 2002 Nov;68(11):1034-6.

PMID: 12451497

Abstract:

By means of HIV gp41 binding affinity directed chromatographic fractionation, three phenylethanoid glycosides; calceolarioside A ( 1), calceolarioside B ( 2) and acteoside ( 3), along with four hydroxycoumarins; esculin ( 4), fraxin ( 5), fraxetin ( 6) and esculetin ( 7), and one lignan, (-)-olivil ( 8) were isolated from the n-butyl alcohol fraction of Fraxinus sieboldiana var. angustata. Among the isolated compounds, calceolarioside B ( 2) and esculetin ( 7) showed moderate binding affinity on HIV gp41 with IC 50 values of 0.1 mg/ml and 0.5 mg/ml, respectively. Calceolarioside A ( 1), calceolarioside B ( 2), acteoside ( 3), and (-)-olivil ( 8) were isolated for the first time from this plant.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP105471985	Calceolarioside B		105471-98-5	Price

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