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Houttuynoid M, an Anti-HSV Active Houttuynoid From Houttuynia Cordata Featuring a Bis-houttuynin Chain Tethered to a Flavonoid Core

Jiao-Jiao Li, Guo-Dong Chen, Hong-Xia Fan, Dan Hu, Zheng-Qun Zhou, Kang-Hua Lan, Hui-Ping Zhang, Hideaki Maeda, Xin-Sheng Yao, Hao Gao

J Nat Prod. 2017 Nov 22;80(11):3010-3013.

PMID: 29099182

Abstract:

Houttuynoid M (1), a new houttuynoid, and the related known compound houttuynoid A (2) were isolated from Houttuynia cordata. Their structures were defined using NMR data analysis, HR-MSn experiment, and chemical derivatization. Houttuynoid M is the first example of a houttuynoid with a bis-houttuynin chain tethered to a flavonoid core. A putative biosynthetic pathway of houttuynoid M (1) is proposed. The anti-herpes simplex virus (anti-HSV) activities of 1 and 2 (IC50 values of 17.72 and 12.42 μM, respectively) were evaluated using a plaque formation assay with acyclovir as the positive control.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP102728643 Acyclovir Related Compound A Acyclovir Related Compound A 102728-64-3 Price
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