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How Well Does Cholesteryl Hemisuccinate Mimic Cholesterol in Saturated Phospholipid Bilayers?

How Well Does Cholesteryl Hemisuccinate Mimic Cholesterol in Saturated Phospholipid Bilayers?

Waldemar Kulig, Joona Tynkkynen, Matti Javanainen, Moutusi Manna, Tomasz Rog, Ilpo Vattulainen, Pavel Jungwirth

J Mol Model. 2014 Feb;20(2):2121.

PMID: 24526383

Abstract:

Cholesteryl hemisuccinate is a detergent that is often used to replace cholesterol in crystallization of membrane proteins. Here we employ atomistic molecular dynamics simulations to characterize how well the properties of cholesteryl hemisuccinate actually match those of cholesterol in saturated protein-free lipid membranes. We show that the protonated form of cholesteryl hemisuccinate mimics many of the membrane properties of cholesterol quite well, while the deprotonated form of cholesteryl hemisuccinate is less convincing in this respect. Based on the results, we suggest that cholesteryl hemisuccinate in its protonated form is a quite faithful mimic of cholesterol for membrane protein crystallization, if specific cholesterol-protein interactions (not investigated here) are not playing a crucial role.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1510210	Cholesteryl hemisuccinate		1510-21-0	Price

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