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Human Basophils Are a Source of - And Are Differentially Activated by - IL-31

Human Basophils Are a Source of - And Are Differentially Activated by - IL-31

U Raap, M Gehring, S Kleiner, U Rüdrich, B Eiz-Vesper, H Haas, A Kapp, B F Gibbs

Clin Exp Allergy. 2017 Apr;47(4):499-508.

PMID: 28000952

Abstract:

Background:
Basophils are important effector cells involved in the pathogenesis of inflammatory skin diseases including chronic urticaria which is associated by increased IL-31 serum levels. So far the effects of IL-31 on human basophils are unknown.
Objective:
To analyse the functional role of IL-31 in basophil biology.
Methods:
IL-31 expression was evaluated in skin samples derived from chronic spontaneous urticaria patients. Oncostatin M receptor (OSMR), IL-31 receptor A (RA) and IL-31 protein expressions were analysed on human basophils from healthy donors. Basophil responses to IL-31 were assessed for chemotaxis, externalization of CD63 and CD203c as well as the release of histamine, IL-4 and IL-13.
Results:
IL-31RA and OSMR were expressed on human basophils. IL-31 was strongly expressed in the skin of patients with chronic spontaneous urticaria and was released from isolated basophils following either anti-IgE, IL-3 or fMLP stimulation. IL-31 induced chemotaxis and the release of IL-4 and IL-13 which was specifically inhibited by anti-IL-31RA and anti-OSMR. Conversely, IL-31 had no effect on CD63 and CD203c externalization or histamine release.
Conclusions and clinical relevance:
Human basophils are a source of -and are activated by - IL-31 with the release of pro-inflammatory cytokines and the induction of chemotaxis indicating an important novel function of IL-31 in basophil biology.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42413393	IL-31 human			Price

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