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Human Chorionic Beta-Mannosidase: Comparison With Beta-Mannosidase From Human Cultured Fibroblasts

Human Chorionic Beta-Mannosidase: Comparison With Beta-Mannosidase From Human Cultured Fibroblasts

N A Petushkova, T S Ivleva, Vozniy YaM

Prenat Diagn. 1992 Oct;12(10):835-9.

PMID: 1475253

Abstract:

The conditions for assay of beta-mannosidase activity in human chorionic villi (CV) were studied using the fluorogenic substrate 4-methylumbelliferyl-beta-D-mannopyranoside. A comparison of the biochemical properties of the CV beta-mannosidase with those of the enzyme from human cultured fibroblasts showed their similarity. Like the enzyme from skin fibroblasts, the CV beta-mannosidase had rather high activity. Both enzymes had virtually the same pH optimum (4.2-4.7) and Km value. The data presented suggest that chorion biopsy specimens can be used for prenatal determination of beta-mannosidase activity at an early stage of development.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP67909302	4-Methylumbelliferyl β-D-mannopyranoside		67909-30-2	Price

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