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Human Embryonic Stem Cell Lines Derived From Discarded Embryos

Human Embryonic Stem Cell Lines Derived From Discarded Embryos

Maisam Mitalipova, John Calhoun, Soojung Shin, David Wininger, Thomas Schulz, Scott Noggle, Alison Venable, Ian Lyons, Allan Robins, Steven Stice

Stem Cells. 2003;21(5):521-6.

PMID: 12968106

Abstract:

Human pluripotent embryonic stem (ES) cells have important potential in regenerative medicine and as models for human preimplantation development; however, debate continues over whether embryos should be destroyed to produce human ES cells. We have derived four ES cell lines on mouse embryonic fibroblast cells in medium supplemented with basic fibroblast growth factor, human recombinant leukemia inhibitory factor, and fetal bovine serum. The source of these cell lines was poor-quality embryos that in the course of routine clinical practice would have been discarded. After continuous proliferation in vitro for more than 12 months, these ES cell lines maintained their developmental potential to form trophoblast and somatic cells, including cardiac muscle and neuronal tissue.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4248639	Stem Cell Factor human			Price

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