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Human IgA-secreting Cells Induced by Intestinal, but Not Systemic, Immunization Respond to CCL25 (TECK) and CCL28 (MEC)

Human IgA-secreting Cells Induced by Intestinal, but Not Systemic, Immunization Respond to CCL25 (TECK) and CCL28 (MEC)

Patrik Sundström, Samuel B Lundin, Lars-Ake Nilsson, Marianne Quiding-Järbrink

Eur J Immunol. 2008 Dec;38(12):3327-38.

PMID: 19003934

Abstract:

Organ-specific homing of lymphoid cells depends on the expression of tissue-specific adhesion molecules and production of specific chemokines. CCL25 (TECK) and CCL28 (MEC) have been reported to direct circulating memory/effector B cells to mucosal tissues. Here, we examined if differential responsiveness to mucosal and systemic chemokines could explain the differential migration pattern of circulating human antibody-secreting cells (ASC), induced by mucosal and systemic immunization. There was a robust migration of specific IgA- and IgM-ASC induced by Salmonella vaccination toward the mucosal chemokines CCL25 and CCL28. In contrast, tetanus-specific ASC migrated to the systemic chemokine CXCL12 (SDF-1alpha) and showed no response to CCL25 or CCL28, not even tetanus-specific IgA-ASC. Cell sorting experiments demonstrated that Salmonella-specific ASC co-expressed CCR9 and CCR10. Our results show that induction site, rather than isotype commitment, determines the chemokine responsiveness and migration pattern of human effector B cells.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42413096	MEC (CCL28) human			Price
IAR4248658	TECK (CCL25) human			Price

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