Home
Resources
Publications
Human Kidney Proximal Tubule Cells Are Vulnerable to the Effects of Rauwolfia Serpentina

Human Kidney Proximal Tubule Cells Are Vulnerable to the Effects of Rauwolfia Serpentina

Miriam E Mossoba, Thomas J Flynn, Sanah Vohra, Paddy L Wiesenfeld, Robert L Sprando

Cell Biol Toxicol. 2015 Dec;31(6):285-93.

PMID: 26838987

Abstract:

Rauwolfia serpentina (or Snake root plant) is a botanical dietary supplement marketed in the USA for maintaining blood pressure. Very few studies have addressed the safety of this herb, despite its wide availability to consumers. Its reported pleiotropic effects underscore the necessity for evaluating its safety. We used a human kidney cell line to investigate the possible negative effects of R. serpentina on the renal system in vitro, with a specific focus on the renal proximal tubules. We evaluated cellular and mitochondrial toxicity, along with a variety of other kidney-specific toxicology biomarkers. We found that R. serpentina was capable of producing highly detrimental effects in our in vitro renal cell system. These results suggest more studies are needed to investigate the safety of this dietary supplement in both kidney and other target organ systems.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP8063170	Rauwolfia Serpentina		8063-17-0	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: