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Human Osteopontin: Potential Clinical Applications in Cancer (Review)

Chengcheng Hao, Yuxin Cui, Sionen Owen, Wenbin Li, Shan Cheng, Wen G Jiang

Int J Mol Med. 2017 Jun;39(6):1327-1337.

PMID: 28440483

Abstract:

Human osteopontin (OPN) is a glycosylated phosphoprotein which is expressed in a variety of tissues in the body. In recent years, accumulating evidence has indicated that the aberrant expression of OPN is closely associated with tumourigensis, progression and most prominently with metastasis in several tumour types. In this review, we present the current knowledge on the expression profiles of OPN and its main splice variants in human cancers, as well as the potential implications in patient outcome. We also discuss its putative clinical application as a cancer biomarker and as a therapeutic target.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
IAR42413804 Osteopontin human Osteopontin human Price
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