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Human Plasma-Derived C1 Esterase Inhibitor Concentrate Has Limited Effect on House Dust Mite-Induced Allergic Lung Inflammation in Mice

Human Plasma-Derived C1 Esterase Inhibitor Concentrate Has Limited Effect on House Dust Mite-Induced Allergic Lung Inflammation in Mice

Ingrid Stroo, Jack Yang, Adam A Anas, J Daan de Boer, Gerard van Mierlo, Dorina Roem, Diana Wouters, Ruchira Engel, Joris J T H Roelofs, Cornelis van 't Veer, Tom van der Poll, Sacha Zeerleder

PLoS One. 2017 Oct 16;12(10):e0186652.

PMID: 29036225

Abstract:

C1 esterase inhibitor (C1-INH) can inhibit multiple pathways (complement, contact-kinin, coagulation, and fibrinolysis) that are all implicated in the pathophysiology of asthma. We explored the effect of human plasma-derived C1-INH on allergic lung inflammation in a house dust mite (HDM) induced asthma mouse model by daily administration of C1-INH (15 U) during the challenge phase. NaCl and HDM exposed mice had comparable plasma C1-INH levels, while bronchoalveolar lavage fluid (BALF) levels were increased in HDM exposed mice coinciding with slightly reduced activation of complement (C5a). C1-INH treatment reduced Th2 response and enhanced HDM-specific IgG1. Influx of eosinophils in BALF or lung, pulmonary damage, mucus production, procoagulant response or plasma leakage in BALF was similar in both groups. In conclusion, C1-INH dampens Th2 responses during HDM induced allergic lung inflammation.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP80295381	C1 Esterase Inhibitor from human plasma		80295-38-1	Price

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