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Human TRPA1 Activation by Terpenes Derived From the Essential Oil of Daidai,

Human TRPA1 Activation by Terpenes Derived From the Essential Oil of Daidai,

Yuko Terada, Rie Yamashita, Nozomi Ihara, Toyomi Yamazaki-Ito, Yuma Takahashi, Haruka Masuda, Satoshi Sakuragawa, Sohei Ito, Keisuke Ito, Tatsuo Watanabe

Biosci Biotechnol Biochem. 2019 Sep;83(9):1721-1728.

PMID: 31072263

Abstract:

Daidai (bitter orange, Citrus aurantium) is characterized by its fresh citrus scent. In Japanese cuisine, its juice is an important ingredient. As tons of industrial waste is obtained while processing the daidai juice, additional utilization of this waste has great social value. In our study, we prepared the essential oil from the waste obtained during daidai juice processing and demonstrated that the oil activates human TRPA1 (hTRPA1). This oil contains 10 types of terpenes, all of which activated hTRPA1 with an EC50 value of 6-167 µM. To our knowledge, this study is the first to show a hTRPA1 activation by five terpenes: linalyl acetate, geranyl acetate, osthole, geranyl propionate, and neryl acetate. Because physiological benefits of TRPA1 agonists, such as enhancement of energy metabolism and promotion of skin barrier recovery, have been reported, the oil could be a promising ingredient for anti-obesity food products and cosmetics.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP141128	Neryl acetate		141-12-8	Price

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