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Hybrid gold/chiral Brønsted Acid Relay Catalysis Allows an Enantioselective Synthesis of (-)-5-epi-eupomatilone-6

Xiang Wu, Ming-Li Li, Pu-sheng Wang

J Org Chem. 2014 Jan 3;79(1):419-25.

PMID: 24328038

Abstract:

An enantioselective synthesis of (-)-5-epi-eupomatilone-6 has been accomplished by using relay catalytic cascade intramolecular hydrosiloxylation and Mukaiyama aldol reaction of 2,3,4-trimethoxy-6-(phenylethynyl)phenyl dimethylsilanol with fluorenylglyoxylate.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP879904822 (N-Boc-2-pyrrolyl)dimethylsilanol (N-Boc-2-pyrrolyl)dimethylsilanol 879904-82-2 Price
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