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Hydrogel Functionalized Janus Membrane for Skin Regeneration

Hydrogel Functionalized Janus Membrane for Skin Regeneration

Young-Hyeon An, Seung Jung Yu, In Seon Kim, Su-Hwan Kim, Jeong-Mi Moon, Seunghyun L Kim, Young Hwan Choi, Joon Sig Choi, Sung Gap Im, Kyung Eun Lee, Nathaniel S Hwang

Adv Healthc Mater. 2017 Mar;6(5).

PMID: 27995759

Abstract:

In this study, a hydrogel functionalized Janus membrane is developed and its capacity is examined as a wound dressing biomaterial. A hydrophobic fluoropolymer, poly(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl methacrylate) (PHFDMA), is uniformly coated onto macroporous polyester membrane through initiated chemical vapor deposition process on both sides. PHFDMA-coated macroporous membrane exhibits antibacterial property, allows air permeation, and inhibits water penetration. Janus membrane property is obtained by exposing one side of PHFDMA coated membrane with 1 m KOH solution, which allows PHFDMA cleavage resulting in carboxylic acid residue. This carboxylic acid residue is then further functionalized with gelatin methacrylate-based photocrosslinkable hydrogel for moisture retention and growth factor release. When applied to full thickness dorsal skin defect model, functionalized hydrogel allows moisture retention and hydrophobic surface prevents exudate leaks via water repellence. Furthermore, hydrogel functionalized Janus membrane enhances the wound healing rate and induces thick epidermal layer formation. In conclusion, the multifunctional Janus membrane with hydrophobic outer surface and immobilized hydrogel on the other surface is fabricated for an innovative strategy for wound healing.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1996889	3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-Heptadecafluorodecyl methacrylate		1996-88-9	Price

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