Home
Resources
Publications
Hydrogel Matrices Based on Elastin and Alginate for Tissue Engineering Applications

Hydrogel Matrices Based on Elastin and Alginate for Tissue Engineering Applications

Raquel Silva, Raminder Singh, Bapi Sarker, Dimitrios G Papageorgiou, Judith A Juhasz-Bortuzzo, Judith A Roether, Iwona Cicha, Joachim Kaschta, Dirk W Schubert, Konstantinos Chrissafis, Rainer Detsch, Aldo R Boccaccini

Int J Biol Macromol. 2018 Jul 15;114:614-625.

PMID: 29572141

Abstract:

Hydrogels from natural polymers are widely used in tissue engineering due to their unique properties, especially when regarding the cell environment and their morphological similarity to the extracellular matrix (ECM) of native tissues. In this study, we describe the production and characterization of novel hybrid hydrogels composed of alginate blended with elastin from bovine neck ligament. The properties of elastin as a component of the native ECM were combined with the excellent chemical and mechanical stability as well as biocompatibility of alginate to produce two hybrid hydrogels geometries, namely 2D films obtained using sonication treatment and 3D microcapsules produced by pressure-driven extrusion. The resulting blend hydrogels were submitted to an extensive physico-chemical characterization. Furthermore, the biological compatibility of these materials was assessed using normal human dermal fibroblasts, indicating the suitability of this blend for soft tissue engineering.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP9007583-A	Elastin from bovine neck ligament		9007-58-3	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: