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Hydrogels for Biomedical Applications From Glycol Chitosan and PEG Diglycidyl Ether Exhibit Pro-Angiogenic and Antibacterial Activity

Hydrogels for Biomedical Applications From Glycol Chitosan and PEG Diglycidyl Ether Exhibit Pro-Angiogenic and Antibacterial Activity

G Tripodo, A Trapani, A Rosato, C Di Franco, R Tamma, G Trapani, D Ribatti, D Mandracchia

Carbohydr Polym. 2018 Oct 15;198:124-130.

PMID: 30092982

Abstract:

We aimed at producing a hydrogel from a chitosan (CS) derivative soluble in physiological conditions to avoid any purification step thus allowing to use the materials also as an in-situ forming material. So, we crosslinked glycol chitosan (GCS) with poly(ethylene glycol) diglycidyl ether (PEGDE) in water at 37 °C. The scaffolds, referred as GCS-PEG, were specifically designed to be used as wound dressing materials as such (after crosslinking) or as in-situ forming materials. Different amounts of PEGDE were tested. The obtained scaffolds showed macroscopic pores and a tailorable swelling in water by controlling the crosslinking degree. Moreover, GCS-PEG scaffolds displayed a significant antimicrobial activity against Staphylococcus aureus. In-vivo study using the chick embryo choriallantoic membrane resulted in a highly pronounced pro-angiogenic activity suggesting important tissue regeneration properties. Moreover, the employed materials are commercially available, no organic solvents are required and the scaling up is quite predictable.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP72207808	Poly(ethylene glycol) diglycidyl ether		72207-80-8	Price

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