Home
Resources
Publications
Hydrophobic Nanoprecipitates of β-Cyclodextrin/Avermectins Inclusion Compounds Reveal Insecticide Activity Against Aedes Aegypti Larvae and Low Toxicity Against Fibroblasts

Hydrophobic Nanoprecipitates of β-Cyclodextrin/Avermectins Inclusion Compounds Reveal Insecticide Activity Against Aedes Aegypti Larvae and Low Toxicity Against Fibroblasts

Ana M Dos Santos Moreira, Vanessa C E Bittencourt, Fábio L S Costa, Maria Elena de Lima, Miriam T P Lopes, Warley S Borges, Gustavo F Martins, Clébio S Nascimento Jr, Jeferson G da Silva, Ângelo M L Denadai, etc.

J Agric Food Chem. 2018 Jul 18;66(28):7275-7285.

PMID: 29925239

Abstract:

In the present work, hydrophobic nanoprecipitates (HNPs) of inclusion complexes formed between β-cyclodextrin (βCD) and the avermectins (AVMs) named eprinomectin (EPRI) and ivermectin (IVER) were synthesized and characterized, and their larvicidal activity against Aedes aegypti and human safety against fibroblasts were evaluated. Initially, thermogravimetric analysis/differential thermal analysis data revealed that inclusion increased the thermal stability of AVMs in the presence of βCD. Nuclear magnetic resonance experiments and density functional theory calculations pointed out the inclusion of the benzofuran ring of the two AVMs in the βCD cavity. Isothermal titration calorimetry experiments allowed identification of different binding constants for EPRI/βCD ( Kb = 1060) and βCD/IVER ( Kb = 1700) systems, despite the structural similarity. Dynamic light scattering titrations of AVMs' dimethyl sulfoxide solution in βCD aqueous solution demonstrated that the formed HNPs have lower sizes in the presence of βCD. Finally, the inclusion of EPRI in βCD increased its larval toxicity and reduced its human cytotoxicity, while for IVER/βCD no beneficial effect was observed upon inclusion. These results were rationalized in terms of structural differences between the two molecules. Finally, the EPRI/βCD complex has great potential as an insecticide against A. aegypti larvae with high human safety.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP123997262-A	Eprinomectin solution		123997-26-2	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: