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[Hydrophobic Nitroxyl Radicals Inhibit Linoleyl Alcohol Oxidation by 5-lipoxygenase]

[Hydrophobic Nitroxyl Radicals Inhibit Linoleyl Alcohol Oxidation by 5-lipoxygenase]

A I Vovk, O V Kharchenko, A I Kharitonenko, V P Kukhar', L B Babiĭ, M G Kazachkov, A K Mel'nik, A N Khil'chevskiĭ

Bioorg Khim. Jul-Aug 2004;30(4):436-40.

PMID: 15469019

Abstract:

The linoleyl alcohol oxidation catalyzed by potato tuber 5-lipoxygenase was found to be efficiently inhibited by stable nitroxyl radicals: 1-oxyl-2,2,6,6-tetramethylpiperidin-4-yl 1-bicyclo[2,2,2]octane-1-carboxylate, 1-adamantylacetate, dodecanoate, and octadecanoate. The dependence of apparent IC50 values on the rotational correlation times of times of 4-hydroxy-1-oxyl-2,2,6,6-tetramethylpiperidine and its derivatives in model micellar systems was analyzed. The inhibition mechanism was proposed; it involves the interaction of hydrophobic nitroxyl radical with the intermediate radical enzyme-substrate complex.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP506434	Linoleyl alcohol		506-43-4	Price

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