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Hypotriglyceridemic and Hypoglycemic Effects of Vescalagin From Pink Wax Apple [Syzygium Samarangense (Blume) Merrill and Perry Cv. Pink] in High-Fructose Diet-Induced Diabetic Rats

Hypotriglyceridemic and Hypoglycemic Effects of Vescalagin From Pink Wax Apple [Syzygium Samarangense (Blume) Merrill and Perry Cv. Pink] in High-Fructose Diet-Induced Diabetic Rats

Szu-Chuan Shen, Wen-Chang Chang

Food Chem. 2013 Jan 15;136(2):858-63.

PMID: 23122137

Abstract:

Vescalagin, an active component from Pink wax apple [Syzygium samarangense (Blume) Merrill and Perry cv. Pink] fruit, with glucose uptake enhancing ability in insulin-resistant FL83B mouse hepatocytes, as shown in our previous study, was further evaluated for its hypotriglyceridemic and hypoglycemic effects in high-fructose diet (HFD)-induced diabetic rats. Wistar rats were fed HFD for 16 weeks and orally administered with vescalagin from Pink wax apple daily during the last 4 weeks. The results of biochemical parameters showed that fasting blood glucose, C-peptide, fructosamine, triglyceride and free fatty acid contents decreased by 44.7%, 46.2%, 4.0%, 42.5%, and 10.8%, respectively, in the HFD-induced diabetic rats administered with vescalagin at 30 mg/kg body weight in comparison with those of control HFD-induced diabetic rats. However, high-density-lipoprotein-cholesterol content increased by 14.4% in the HFD rats treated with vescalagin. The present study reveals that vescalagin could have therapeutic value against diabetic progression via its anti-hypertriglyceridemic and anti-hyperglycemic effects.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP36001475	Vescalagin		36001-47-5	Price

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