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Hypovolemia, Hyperosmolality, and Acidosis Associated With Intraperitoneal Infusion of Nitrofurazone Solution in Healthy Horses

K A Gossett, D J McCoy, P L Jowett, M T Kearney

Am J Vet Res. 1988 Sep;49(9):1601-4.

PMID: 3223672

Abstract:

Nitrofurazone solution containing 0.2% nitrofurazone and 99.8% polyethylene glycol was given to 4 healthy horses (2 L in 2 L of lactated Ringer solution, intraperitoneally). Horses developed hypovolemia, hyperosmolality, and mixed respiratory and metabolic acidosis. These changes were largely attributable to polyethylene glycol, but a contribution of nitrofurazone cannot be excluded. Intraperitoneal infusion of nitrofurazone solution in horses is contraindicated.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP59870-A Nitrofurazone solution Nitrofurazone solution 59-87-0 Price
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