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Hypoxia Protects Neuronal Cells From Human Prion Protein Fragment-Induced Apoptosis

Hypoxia Protects Neuronal Cells From Human Prion Protein Fragment-Induced Apoptosis

Jae-Suk Seo, Jae-Won Seol, Myung-Hee Moon, Jae-Kyo Jeong, You-Jin Lee, Sang-Youel Park

J Neurochem. 2010 Feb;112(3):715-22.

PMID: 19919574

Abstract:

Prion diseases are neurodegenerative disorders characterized by the accumulation of an abnormal isoform of the prion protein PrP(Sc). Human prion protein fragment, PrP (106-126) (prion protein peptide 106-126), may contain most of the pathological features associated with PrP(Sc). Hypoxic conditions elicit cellular responses adaptively designed to improve cell survival and have an important role in the process of cell survival. We investigate the effects of hypoxia on PrP (106-126)-induced apoptosis in the present study. Human neuroblastoma and glioblastoma cells were incubated with varied doses of PrP (106-126) under both normoxic or hypoxic conditions, in order to determine the regulatory effects of hypoxia on PrP (106-126)-induced apoptosis. The results indicate that hypoxia protects neuronal cells against PrP (106-126)-induced cell death by activating the Akt signal, which is inactivated by prion proteins, and inhibiting PrP (106-126)-induced caspase 3 activation. Low oxygen conditions increase the Bcl-2 protein, which is associated with anti-apoptotic signals, and recover the PrP (106-126)-induced reduction in mitochondrial transmembrane potential. This study demonstrates that hypoxia inhibits PrP (106-126)-induced neuron cell death by regulating Akt and Akt-related signaling, and it also suggests that prion-related neuronal damage and disease may be regulated by hypoxia or by hypoxic-inducing genes.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP148439490	Prion Protein Fragment 106-126 Human		148439-49-0	Price

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