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I 2/CuCl 2-promoted one-pot three-component synthesis of aliphatic or aromatic substituted 1,2,3-thiadiazoles

I 2/CuCl 2-promoted one-pot three-component synthesis of aliphatic or aromatic substituted 1,2,3-thiadiazoles

Can Wang, Xiao Geng, Peng Zhao, You Zhou, Yan-Dong Wu, Yan-Fang Cui, An-Xin Wu

Chem Commun (Camb). 2019 Jul 18;55(56):8134-8137.

PMID: 31240291

Abstract:

An efficient I2/CuCl2-promoted one-pot three-component strategy for the construction of 1,2,3-thiadiazoles from aliphatic- or aromatic-substituted methyl ketones, p-toluenesulfonyl hydrazide, and potassium thiocyanate has been developed. Simple and commercially available starting materials, a broad substrate scope, and excellent functional group tolerability make this strategy practical for applications. Furthermore, 1,2,3-thiadiazole synthesis was realized by using potassium thiocyanate as an odorless sulfur source.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS7931502	Potassium 1-(p-toluenesulfonyl)pyrrole-2-trifluoroborate			Price

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