Home
Resources
Publications
Ibuprofen and Lipoic Acid Codrug 1 Control Alzheimer's Disease Progression by Down-Regulating Protein Kinase C ε-mediated Metalloproteinase 2 and 9 Levels in β-amyloid Infused Alzheimer's Disease Rat Model

Ibuprofen and Lipoic Acid Codrug 1 Control Alzheimer's Disease Progression by Down-Regulating Protein Kinase C ε-mediated Metalloproteinase 2 and 9 Levels in β-amyloid Infused Alzheimer's Disease Rat Model

S Zara, M Rapino, P Sozio, A Di Stefano, C Nasuti, A Cataldi

Brain Res. 2011 Sep 15;1412:79-87.

PMID: 21820649

Abstract:

Alzheimer's disease (AD) commonly begins with loss of recent memory and is associated to pathological and histological hallmarks such as β amyloid plaques, neural tangles (NFT), cholinergic deficit, extensive neuronal loss and synaptic changes in the cerebral cortex and hippocampus. The amyloid cascade hypothesis implies the activity of β, γ secretases which mediate the cleavage of APP (Amyloid Precursor Protein), the formation of amyloidogenic Aβ fragment (1-42), which compacts into amyloid plaques, while the cleavage by α secretase of APP, within the Aβ segment (non-amyloidogenic processing) forms sAPP and prevents the formation of Aβ. Among the proteases which have Aβ-degrading activity, Metalloproteinase (MMP) 2, disclosing β secretase-like activity, is included, while MMP9 seems to contribute to neuronal death. In addition, since intracellular signaling protein kinase C (PKC) can control either directly α secretase or indirectly through regulation of ERK1/2, preventing the formation of β amyloid, created by β and γ secretase, and prolonging the life span of Alzheimer's disease mutant mice, here we show the effects exerted by new codrug 1 on PKC ε-mediated MMP2 and MMP9 levels regulation in Aβ (1-40) infused rat cerebral cortex. Interestingly codrug 1, lowering metalloproteinases expression via PKC ε down-modulation, seems to control Alzheimer's disease induced cerebral amyloid deposits, neuronal death and, lastly, behavioral deterioration.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP107761422-A	Amyloid β Protein Fragment 1-42		107761-42-2	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: