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Ibuprofen-conjugated hyaluronate/polygalacturonic Acid Hydrogel for the Prevention of Epidural Fibrosis

Ibuprofen-conjugated hyaluronate/polygalacturonic Acid Hydrogel for the Prevention of Epidural Fibrosis

Cheng-Yi Lin, Hsiu-Hui Peng, Mei-Hsiu Chen, Jui-Sheng Sun, Chih-Ju Chang, Tse-Ying Liu, Ming-Hong Chen

J Biomater Appl. 2016 May;30(10):1589-600.

PMID: 26935813

Abstract:

The formation of fibrous tissue is part of the natural healing response following a laminectomy. Severe scar tissue adhesion, known as epidural fibrosis, is a common cause of failed back surgery syndrome. In this study, by combining the advantages of drug treatment with a physical barrier, an ibuprofen-conjugated crosslinkable polygalacturonic acid and hyaluronic acid hydrogel was developed for epidural fibrosis prevention. Conjugation was confirmed and measured by 1D(1)H NMR spectroscopy.In vitroanalysis showed that the ibuprofen-conjugated polygalacturonic acid-hyaluronic acid hydrogel showed low cytotoxicity. In addition, the conjugated ibuprofen decreased prostaglandin E2production of the lipopolysaccharide-induced RAW264.7 cells. Histological data inin vivostudies indicated that the scar tissue adhesion of laminectomized male adult rats was reduced by the application of our ibuprofen-conjugated polygalacturonic acid-hyaluronic acid hydrogel. Its use also reduced the population of giant cells and collagen deposition of scar tissue without inducing extensive cell recruitment. The results of this study therefore suggest that the local delivery of ibuprofenviaa polygalacturonic acid-hyaluronic acid-based hydrogel reduces the possibility of epidural fibrosis.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP25990107	Polygalacturonic acid		25990-10-7	Price

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