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Identification and Regional Localization of a Human IMP Dehydrogenase-Like Locus (IMPDHL1) at 16p13.13

Identification and Regional Localization of a Human IMP Dehydrogenase-Like Locus (IMPDHL1) at 16p13.13

N A Doggett, D F Callen, Z L Chen, S Moore, J G Tesmer, L A Duesing, R L Stallings

Genomics. 1993 Dec;18(3):687-9.

PMID: 7905856

Abstract:

Sequence-tagged sites (STSs) are versatile chromosomal markers for a variety of genome mapping efforts. In this report, we describe a randomly generated STS (323F4) from human chromosome 16 genomic DNA that has 90.0% sequence identity to the type I human inosine-5'-monophosphate dehydrogenase (IMPDH1) gene and 72% identity to the type II human inosine-5'-monophosphate dehydrogenase (IMPDH2) gene. Additional sequencing by primer walking has provided a total of 1380 bp of the human chromosome 16 sequence. The IMPDH-like sequence 323F4 was regionally localized by PCR analysis of a panel of somatic cell hybrids containing different portions of human chromosome 16 to 16p13.3-13.12, between the breakpoints found in hybrids CY196/CY197 and CY198. This regional mapping assignment was further refined to subband 16p13.13 by high-resolution fluorescence in situ hybridization using cosmid 323F4 as a probe. We conclude that a third, previously undescribed IMPDH locus, termed IMPDHL1, exists at human chromosome 16p13.13.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42415137	Inosine Monophosphate Dehydrogenase Type II human			Price

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