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Identification of 3-nitro-L-tyrosine, a Product of Nitric Oxide and Superoxide, as an Indicator of Oxidative Stress in the Human Brain

Identification of 3-nitro-L-tyrosine, a Product of Nitric Oxide and Superoxide, as an Indicator of Oxidative Stress in the Human Brain

W Maruyama, Y Hashizume, K Matsubara, M Naoi

J Chromatogr B Biomed Appl. 1996 Feb 9;676(1):153-8.

PMID: 8852056

Abstract:

3-Nitro-L-tyrosine synthesized from L-tyrosine by peroxynitrite, a product of superoxide and nitric oxide, was identified for the first time in human brains. By quantitative analysis using high-performance liquid chromatography with multi-electrochemical detectors, 3-nitro-L-tyrosine concentration in the gray matter was higher in the cerebrum than in the cerebellum; 0.96 and 0.29 nmol/g wet weight, respectively. On the other hand, L-tyrosine concentration was not different. 3-Nitro-L-tyrosine in the brain may be used as an indicator of oxidative stress induced by reactive oxygen species and nitric oxide.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP621443	3-Nitro-L-tyrosine		621-44-3	Price

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