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Identification of 4'-O-β-D-glucosyl-5-O-methylvisamminol as a Novel Epigenetic Suppressor of Histone H3 Phosphorylation at Ser10 and Its Interaction With 14-3-3ε

Identification of 4'-O-β-D-glucosyl-5-O-methylvisamminol as a Novel Epigenetic Suppressor of Histone H3 Phosphorylation at Ser10 and Its Interaction With 14-3-3ε

Jong-Su Kang, Young-Won Chin, Kyeong Lee, Young-Woo Kim, Bu Young Choi, Young-Sam Keum

Bioorg Med Chem Lett. 2014 Oct 1;24(19):4763-4767.

PMID: 25205188

Abstract:

Natural compounds are regarded as a rich source for potential anti-inflammatory and anti-carcinogenic agents. Increasing evidence indicates that histone phosphorylation at Ser10 is a marker for cell cycle progression during the mitosis and the induction of immediate pro-inflammatory genes during the interphase. In the present study, we have screened our in-house natural compounds to find out new chemical inhibitor(s) of histone H3 phosphorylation at Ser10. As a result, we observed that α-amyrin, oleanolic acid, marliolide, and 4'-O-β-D-glucosyl-5-O-methylvisamminol decreased the levels of histone H3 phosphorylation at Ser10 and c-Jun. In particular, we observed that 4'-O-β-D-glucosyl-5-O-methylvisamminol suppressed the direct interaction of histone H3 with 14-3-3ε, inhibited the aurora B kinase activity and delayed the mitotic cell cycle progression. We reports 4'-O-β-D-glucosyl-5-O-methylvisamminol as the first epigenetic natural chemical inhibitor that can abrogates the mitotic cell cycle progression and immediate pro-inflammatory gene expressions via suppression of histone H3 phosphorylation at Ser10 and its interaction with 14-3-3ε.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP80681421	5-O-Methylvisamminol		80681-42-1	Price
AP84272855	4′-O-β-D-Glucosyl 5-O-methylvisamminol		84272-85-5	Price

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