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Identification of a New Synaptic Vesicle Protein 2B mRNA Transcript Which Is Up-Regulated in Neurons by Amyloid Beta Peptide Fragment (1-42)

Identification of a New Synaptic Vesicle Protein 2B mRNA Transcript Which Is Up-Regulated in Neurons by Amyloid Beta Peptide Fragment (1-42)

K Heese, Y Nagai, T Sawada

Biochem Biophys Res Commun. 2001 Dec 21;289(5):924-8.

PMID: 11741278

Abstract:

The treatment of Alzheimer's disease (AD) remains a major challenge because of the incomplete understanding of the triggering events that lead to the selective neurodegeneration characteristic of AD brains. Here we describe a new transcript of synaptic vesicle protein 2B (SV2Bb) mRNA that is up-regulated at mRNA level in neurons by amyloid beta peptide (Abeta) fragment (1-42). In comparison to SV2B this new mRNA encodes for the same protein but it has an elongated 3'-untranslated region (3'UTR) that contains several AU-rich (AUR) cis-acting elements which are probably involved in posttranscriptional regulating of SV2Bb translation. In conclusion, alteration of SV2B(b) expression appears to be involved in processes of neuronal degeneration.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP107761422-A	Amyloid β Protein Fragment 1-42		107761-42-2	Price

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