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Identification of a Propantheline Analog in Propantheline Bromide Tablets

B L Ford, A K Wall, M A Johnston, A R Lea

J Assoc Off Anal Chem. Sep-Oct 1984;67(5):934-9.

PMID: 6501158

Abstract:

A major impurity in a sample of propantheline bromide tablets has been identified as 9-hydroxypropantheline on the basis of the proton magnetic resonance (PMR) and mass spectra (MS). This identification was confirmed by methanolysis of the tablet extract, which yielded a mixture of methyl xanthanoate and methyl 9-hydroxyxanthanoate. A liquid chromatographic (LC) procedure is described which will permit quantitation of 9-hydroxypropantheline bromide in the presence of propantheline bromide, xanthone, and xanthanoic acid.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP82075 Xanthanoic acid Xanthanoic acid 82-07-5 Price
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