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Identification of bioactives from Astragalus chinensis L.f. and their antioxidant, anti-inflammatory and anti-proliferative effects

Ting Hu, Qi-Mei Liu, Xiao-Wei He, Fei Huang, Ming-Wei Zhang, Jian-Guo Jiang

J Food Sci Technol. 2017 Dec;54(13):4315-4323.

PMID: 29184237

Abstract:

This work was designed to obtain the valuable compounds with antioxidant, anti-proliferative and anti-inflammatory activities from Astragalus chinensis. Ethyl acetate fraction obtained from A. chinensis L.f. had significant antioxidant, anti-proliferative and anti-inflammatory activities. Subsequently, five single compounds were separated and purified, which were identified as formononetin (1), rhamnocitrin (2), calycosin (3), β-daucosterol (4), rhamnocitrin-3-O-β-d-glucoside (5). The results displayed that formononetin and rhamnocitrin exhibited significant cytotoxicity actions against tumor cell lines. Calycosin exerted the strongest anti-inflammatory effect of inhibition effects on NO production in macrophages.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP569926 Rhamnocitrin Rhamnocitrin 569-92-6 Price
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