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Identification of Diarylsulfonamides as Agonists of the Free Fatty Acid Receptor 4 (FFA4/GPR120)

Steven M Sparks, Grace Chen, Jon L Collins, Dana Danger, Steven T Dock, Channa Jayawickreme, Stephen Jenkinson, Christopher Laudeman, M Anthony Leesnitzer, Xi Liang, Patrick Maloney, David C McCoy, David Moncol, etc.

Bioorg Med Chem Lett. 2014 Jul 15;24(14):3100-3.

PMID: 24881566

Abstract:

The exploration of a diarylsulfonamide series of free fatty acid receptor 4 (FFA4/GPR120) agonists is described. This work led to the identification of selective FFA4 agonist 8 (GSK137647A) and selective FFA4 antagonist 39. The in vitro profile of compounds 8 and 39 is presented herein.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP349085821 GSK137647A GSK137647A 349085-82-1 Price
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