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Identification of Hydroxybenzoic Acids as Selective Lactate Receptor (GPR81) Agonists With Antilipolytic Effects

Curt A Dvorak, Changlu Liu, Jonathan Shelton, Chester Kuei, Steven W Sutton, Timothy W Lovenberg, Nicholas I Carruthers

ACS Med Chem Lett. 2012 Jun 11;3(8):637-9.

PMID: 24900524

Abstract:

Following the characterization of the lactate receptor (GPR81), a focused screening effort afforded 3-hydroxybenzoic acid 1 as a weak agonist of both GPR81 and GPR109a (niacin receptor). An examination of structurally similar arylhydroxy acids led to the identification of 3-chloro-5-hydroxybenzoic acid 2, a selective GPR81 agonist that exhibited favorable in vivo effects on lipolysis in a mouse model of obesity.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP53984364 3-Chloro-5-hydroxybenzoic acid 3-Chloro-5-hydroxybenzoic acid 53984-36-4 Price
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