Home
Resources
Publications
Identification of KDN-Gangliosides

Identification of KDN-Gangliosides

Ken Kitajima

Methods Mol Biol. 2018;1804:429-435.

PMID: 29926423

Abstract:

KDN is an abbreviated name of 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid, and belongs to sialic acid members like N-acetylneuraminic acid (Neu5Ac), and N-glycolylneuraminic acid (Neu5Gc). The aminoacyl group at C5 position of Neu5Ac is replaced by a hydroxyl group in KDN. Like Neu5Ac, KDN exists in various glycoconjugates including glycosphingolipids in vertebrates and gram-negative bacteria. Because of its unique properties, some methods are specifically applicable to KDN residue, although most detection methods for Neu5Ac are also applicable. In this chapter, methods for identification of KDN residues in glycosphingolipids are described, focusing on two methods that are often used, i.e., the fluorescent HPLC analysis and the TLC immunostaining with the antibodies specific to α2,3- and α2,8-KDN residues.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP22594612	KDN		22594-61-2	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: