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Identification of p(4')-hydroxyantipyrine as a Metabolite of Antipyrine in Man

Identification of p(4')-hydroxyantipyrine as a Metabolite of Antipyrine in Man

T Inaba, H Uchino, W Kalow

Res Commun Chem Pathol Pharmacol. 1981 Jul;33(1):3-8.

PMID: 7268206

Abstract:

Several metabolites of antipyrine have been known for many years, but their recovery does not fully account for the drug in man. During the development of a HPLC assay of 3-hydroxymethylantipyrine, a major metabolite of antipyrine, the presence of another metabolite was noted. Its structure was postulated to be p(4')-hydroxyantipyrine (pOHA) on the basis of chemical derivatization and of mass spectrometry. The structure was confirmed by physicochemical comparison with a synthetic compound. The amount of pOHA in man is small, representing about 2-4% of the dose and less than 1% in the rat.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1672635	4-Hydroxyantipyrine		1672-63-5	Price

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