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Identification of the Major Urinary and Fecal Metabolites of 3,5-dinitrobenzamide in Chickens and Rats

Identification of the Major Urinary and Fecal Metabolites of 3,5-dinitrobenzamide in Chickens and Rats

N W Shappell, G L Larsen, J E Bakke

Chemosphere. 1999 Apr;38(8):1757-62.

PMID: 10101847

Abstract:

Colostomized chickens given oral doses of 3,5-dinitrobenzamide (nitromide) cleared nitromide predominantly through the urine (58% of dose) and feces (21% of dose). Rats cleared 52% of nitromide via urinary excretion and 44% via feces. Major urinary metabolites for both chickens and rats include: 3-amino-5-nitrobenzamide, 3-acetamido-5-nitrobenzamide, 3-acetamide-5-aminobenzamide, and 3,5-diacetamidobenzamide. The major fecal metabolite in chickens was 3-acetamido-5-nitrobenzamide (67% of fecal 14C) and 3-acetamido-5-aminobenzamide in rats (approximately 50%).

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP121813	Nitromide		121-81-3	Price

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