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Identification of Two Novel Human CD1E Alleles

Identification of Two Novel Human CD1E Alleles

I Mirones, M Oteo, J F Parra-Cuadrado, E Martínez-Naves

Tissue Antigens. 2000 Aug;56(2):159-61.

PMID: 11019917

Abstract:

CD1 is a family of proteins structurally related to major histocompatibility complex (MHC) molecules and specialized in presenting lipids or glycolipids to T cells. In humans, there are five CD1 genes (CD1A to CD1E). It has been shown that, in contrast with classical MHC genes, CD1 loci display a very limited polymorphism. In the present work we describe two novel CD1E alleles found in two healthy Caucasian individuals. One allele differs from the wild-type by a point mutation resulting in a replacement of arginine at position 154 by a tryptophan. In the second allele we found a substitution of the leucine 184 by a proline.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42413150	CD1E human			Price

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