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Identification, Preparation, and Characterization of Several Polymorphs and Solvates of Terazosin Hydrochloride

J Bauer, J Morley, S Spanton, F J J Leusen, R Henry, S Hollis, W Heitmann, A Mannino, J Quick, W Dziki

J Pharm Sci. 2006 Apr;95(4):917-28.

PMID: 16493591

Abstract:

The phenomenon of polymorphism is prevalent in pharmaceuticals, yet it is unusual to identify more than three or four forms for any particular drug. Terazosin hydrochloride has been found to exist at room temperature in four solvent-free forms that can be isolated directly, one solvent-free form that can be prepared by desolvation of a methanolate, a methanol solvate, and a dihydrate. This study presents characterization and methods for preparation of each of these forms. Data are also presented demonstrating the relative stability of these forms.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP70024407 Terazosin hydrochloride Terazosin hydrochloride 70024-40-7 Price
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