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Idiotypic-anti-idiotypic Regulation of Antibody Synthesis in Rabbits

Idiotypic-anti-idiotypic Regulation of Antibody Synthesis in Rabbits

P A Cazenave

Proc Natl Acad Sci U S A. 1977 Nov;74(11):5122-5.

PMID: 270748

Abstract:

Anti-ribonuclease antibodies (Ab1) of one rabbit were used to prepare in two other rabbits anti-idiotypic antibodies (Ab2) against them. Anti-idiotypic antibodies (Ab3) were prepared against Ab2 of one rabbit in two other rabbits that had the same phenotype as the former three for the allotypic a and b systems. After a rest period of 4 months, the latter two rabbits were immunized against ribonuclease. The antibodies produced (Ab1') crossreacted with the two anti-idiotypic sera (Ab2) against Ab1, showing an idiotypic similarity between anti-ribonuclease Ab1' and anti-ribonuclease Ab1. No such crossreaction was observed between the anti-idiotypic sera (Ab2) against Ab1 and any of the 12 unrelated antisera against ribonuclease that were tested. These results suggest (i) that rabbits, at least with the same allotypes, possess a closely related idiotypic repertoire; and (ii) that the immune system is a network of variable (V)-domains.

Chemicals Related in the Paper:

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IAR42412739	Anti-TSC2 (ab2) antibody produced in rabbit	Price
IAR42414090	Anti-P4HB (AB2) antibody produced in rabbit	Price
IAR42414431	Anti-MMP19 (AB1) antibody produced in rabbit	Price
IAR4246968	Anti-EDG8 (AB2) antibody produced in rabbit	Price
IAR4248126	Anti-ZDHHC17 (AB1) antibody produced in rabbit	Price

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