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IDPH-8261--a New Nonsteroidal Antiinflammatory Agent

IDPH-8261--a New Nonsteroidal Antiinflammatory Agent

C S Rao, P P Singh, A Y Junnarkar, N Muralidhar, B S Trivedi, B E Rao

Indian J Exp Biol. 1995 Jan;33(1):28-33.

PMID: 9135671

Abstract:

IDPH-8261, methyl alpha-methyl-4-(3-thienyl)benzeneacetate, exhibited marked anti-inflammatory activity in acute, subacute and chronic models of inflammation. In rats, IDPH-8261 exhibited a dose related inhibition of carrageenin-induced rat paw edema and the inhibition was greater than ibuprofen, phenylbutazone, but was three times less than indomethacin. It exhibited anti-inflammatory activity in normal and adrenalectomized rats. It also exhibited the activity against various phlogistic agents. IDPH-8261 exhibited AI activity in subacute granuloma tests. In adjuvant-induced established polyarthritis. IDPH-8261 exhibited anti-arthritic effect at a very low dose (ED50 = 4 mg/kg, p.o.). Ulcerogenic liability was the lowest (UD50 = 180 mg/kg, p.o.), when compared to reference standard drugs. Low toxicity and high efficacy may make this compound a potentially useful therapeutic agent.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP2882157	Indomethacin Related Compound A		2882-15-7	Price

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