0

IFNγ in Combination With IL-7 Enhances Immunotherapy in Two Rat Glioma Models

Sara Fritzell, Sofia Eberstål, Emma Sandén, Edward Visse, Anna Darabi, Peter Siesjö

J Neuroimmunol. 2013 May 15;258(1-2):91-5.

PMID: 23528658

Abstract:

Peripheral immunization, using a combination of interferon-gamma (IFNγ)- and interleukin-7 (IL-7)-producing tumor cells, eradicated 75% of pre-established intracerebral N32 rat glioma tumors, and prolonged survival in the more aggressive RG2 model. Rats immunized with IFNγ- and IL7-transduced N32 cells displayed increases in IFNγ plasma levels and proliferating circulating T cells when compared with rats immunized with N32-wild type cells. Following irradiation, the expression of MHC I and II was high on N32-IFNγ cells, but low on RG2-IFNγ cells. In conclusion, IFNγ and IL-7 immunizations prolong survival in two rat glioma models.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
IAR42413274 IL-7 from rat IL-7 from rat Price
qrcode