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IFN-lambda1 (IL-29) Inhibits GATA3 Expression and Suppresses Th2 Responses in Human Naive and Memory T Cells

IFN-lambda1 (IL-29) Inhibits GATA3 Expression and Suppresses Th2 Responses in Human Naive and Memory T Cells

Jihong Dai, Nicholas J Megjugorac, Grant E Gallagher, Raymond Y L Yu, Grant Gallagher

Blood. 2009 Jun 4;113(23):5829-38.

PMID: 19346497

Abstract:

IFN-lambda1 (IL-29) plays a novel, emerging role in the inhibition of human Th2 responses. Here, we demonstrate that both naive and memory human CD4(+) T cells express mRNA for the IFN-lambda1-specific receptor, IL-28Ralpha, and are responsive to IFN-lambda1. Expression of Th2 cytokines (IL-4 and IL-13) was suppressed in naive and memory CD4(+) T cells by IFN-lambda1, without affecting their proliferation. Further, acquisition of IL-4Ralpha expression after stimulation was inhibited by IFN-lambda1, as was GATA3 expression. Finally, IFN-lambda1 diminished the change in cell-surface phenotype that accompanies differentiation of "central memory" T cells into "effector memory" T cells. Taken together, our data describe unique immunomodulatory effects of IFN-lambda1 and identify novel mechanisms for the reduction of existing Th2 responses and the regulation of new ones, in circulating naive and memory CD4(+) T cells.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42413323	IFN-LAMBDA1 human			Price

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