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IGF Binding protein-5 Synthesis Is Regulated by Testosterone Through Transcriptional Mechanisms in Androgen Responsive Cells

Atsuko Yoshizawa, Sayaka Ogikubo

Endocr J. 2006 Dec;53(6):811-8.

PMID: 17001112

Abstract:

We found that androgen and IGF-I up-regulated IGFBP-5 mRNA in androgen-responsive normal human fibroblast, which was blocked by co-treatment with 5,6-dichloro-1-beta-D-ribofuranosyl-benzimidazole, but not cycloheximide. IGFBP-5 promoter activity was stimulated by androgen. Nuclear run-on assay revealed that IGFBP-5 transcripts were increased in response to androgen, which was not enhanced by co-addition of IGF-I. These results collectively indicate that IGFBP-5 synthesis is regulated by androgen through transcriptional mechanisms in androgen responsive cells.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
IAR42413309 IGF-Binding Protein-5 human IGF-Binding Protein-5 human Price
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