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IGF-I and IGFBP-3 Transport in the Rat Heart

IGF-I and IGFBP-3 Transport in the Rat Heart

Mary Boes, Brian L Dake, Barbara A Booth, Alexander Sandra, Mathew Bateman, Kevin L Knudtson, Robert S Bar

Am J Physiol Endocrinol Metab. 2003 Jan;284(1):E237-9.

PMID: 12485812

Abstract:

Specific binding of IGF-binding protein (IGFBP)-3 was shown to be present in the isolated, beating rat heart. The uptake of perfused (125)I-labeled IGF-I in the beating heart was decreased to 9% by blocking IGF-I binding sites with the IGF-I analog Long R(3) (LR(3)) IGF-I. When LR(3) was perfused with complexes of (125)I-IGF-I. IGFBP-3, uptake of (125)I-IGF-I was decreased to 41%, which was significantly greater than LR(3) and (125)I-IGF-I (41 vs. 9%). These data suggest that both microvessel IGF-I and IGFBP-3 binding sites contribute to the transport of IGF-I in the perfused rat heart. This also suggests a novel and plausible mechanism whereby circulating IGFs reach sites of IGF bioactivity.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4248159	IGF-I from rat			Price

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