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IL-11 Expression in Human Term Placental Macrophages

IL-11 Expression in Human Term Placental Macrophages

Oleg V Pavlov, Natalia L Kramareva, Sergei A Selkov

Am J Reprod Immunol. 2011 Apr;65(4):397-402.

PMID: 20712807

Abstract:

Problem:
IL-11 is a cytokine with pleiotropic activities, including gestational effects. Whereas IL-11 production by maternal reproductive tissues is extensively studied, there is poor information about IL-11 sources in the fetal counterpart of the maternal-fetal unit.
Method of study:
We investigated the expression of IL-11 in the purified human term placenta macrophages, using flow cytometry and immunoenzyme assay.
Results:
Intracellular IL-11 was detected in a substantial proportion of cultured CD68(+) cells (median 38%). IL-11 secretion by the placental macrophages was observed after 23-hr cultivation (median 4.3 pg/10(5) cells). Stimulation with lipopolysaccharide did not significantly change both intracellular expression and secretion of the cytokine.
Conclusion:
Demonstrated IL-11 expression by placental macrophages suggests that non-trophoblast cells contribute to IL-11 production at the maternal-fetal interface and thus account for the reproductive effects of the cytokine.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4248649	IL-11 human			Price

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